US National Cancer Institute,  BRCA1 and BRCA2: Cancer Risk and Genetic Testing, April 1, 2015  BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged DNA and, therefore, play a role in ensuring the stability of the cell's genetic material. When either of these genes is mutated...

Nature  Chromosomal translocations that generate in-frame oncogenic gene fusions are notable examples of the success of targeted cancer therapies1,2,3. We have previously described gene fusions of FGFR3-TACC3 (F3–T3) in 3% of human glioblastoma cases4. Subsequent studies have reported similar frequencies of F3–T3 in many other cancers, indicat...

Cancer Research UK The immune system protects the body against illness and infection caused by bacteria, viruses, fungi or parasites. It is a collection of reactions and responses that the body makes to damaged cells or infection. So it is sometimes called the immune response. The immune system is important to cancer patients in many ways because: ...

Yves A. DeClerck ​ In this issue of Cancer Research , a seminal article from Lavick and Baumann published in the Journal in 1943 is highlighted in celebration of the Journal's 75th anniversary. In this article, the authors, following an earlier observation made in 1939 that diet restriction inhibited the formation of ultraviolet-induced tumors in m...

NHS UK   Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas – a large gland that's part of the digestive system.  Around half of all new cases are diagnosed in people aged 75 or over. It's uncommon in people under 40 years of age. Symptoms of pancreatic cancer In the early stages, a tumour in...